Indium oxide cubes have been prepared by hydrothermal synthesis. The cubes exhibited significantly better catalytic activity towards CO oxidation compared to commercial In2O3 powder and nanoparticles. With the addition of a metal co-catalyst, the performance could be further improved, with the T-50 temperatures (temperature at which 50% of CO is converted) obtained for different metals exhibiting the following trend: Pd > Cu > Pt. The obtained results clearly demonstrate the potential of In2O3 as an active oxide support for CO oxidation. (C) 2015 Elsevier B.V. All rights reserved.