화학공학소재연구정보센터
Journal of Fermentation and Bioengineering, Vol.81, No.5, 367-373, 1996
Analysis of the Immunomagnetic Adhesion of the Common Acute Lymphoblastic-Leukemia Antigen-Carrying Cells
Magnetic beads coated with monoclonal antibodies (MAb) were used to specifically remove cells carrying the common acute lymphoblastic leukemia antigen (cALLA). The target-cell elimination effectiveness (TEE) was found to be kinetically controled, and can be quantitatively described by a model where antigen-carrying cells and MAb-coated magnetic beads are described as colloidal particles. This model can correctly explain the temperature effect on the immunomagnetic cell adhesion where models based on antigen-antibody interaction failed.