[6]-Gingerol (6 % w/v)-loaded cellulose acetate (12 % w/v CA; MW similar to 3 x 10(4) g/mol) fibers (375 +/- A 107 nm) were prepared by electrospinning at 7.5 kV. ATR-FTIR spectra indicated that the mixture was miscible at this composition. Differential scanning calorimetry revealed that [6]-gingerol was uniformly dispersed in the CA matrix and interrupted the hydrogen bond formation among the CA chains. Controlled release study showed that similar to 97 % of the loaded [6]-gingerol could be released from the loaded fibers to the acetate buffer solution at 37 A degrees C, whereas only similar to 74 % of it could be done from the corresponding films. About 92 % of [6]-gingerol in the fibers was dramatically released within 4 h. Release was mainly governed by a diffusion-controlled mechanism. The radical scavenging assay showed antioxidant activity of the loaded fibers. The in vitro cytotoxicity test revealed that the viability of L-929 mouse fibroblast cells to the loaded fibers was similar to 65 %.