A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)-co-poly(N-isopropylacrylamide) (PNIPAAm)-co-poly (epsilon-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(epsilon-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31 degrees C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling-deswelling transition, making them have potential application in long-term drug delivery. POLYM. ENG. SCI., 55:223-230, 2015. (c) 2014 Society of Plastics Engineers