화학공학소재연구정보센터
Journal of Fermentation and Bioengineering, Vol.83, No.4, 395-396, 1997
Asymmetric Bioreduction of Cyclohexylphenyl Ketone to Its Corresponding Alcohol (+)Cyclohexylphenyl Alcohol by the Yeast Candida-Magnoliae My-1785
The screening of 129 fungal and yeasts strains yielded Candida magnoliae MY 1785 as a suitable biocatalyst for the asymmetric bioreduction of cyclohexylphenyl ketone to its corresponding alcohol. Preparative amounts of pure alcohol were prepared and purified. Polarimetry and chiral HPLC analyses indicated that C. magnoliae produced the (+) cyclohexylphenyl alcohol with an enantiomeric excess of 75%. A 55% bioconversion yield was achieved at the preparative scale.