Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate-Carboxy Methyl Guar Gum (Alg-CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350-400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate-CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 degrees C after 8 h incubation. (C) 2014 Elsevier Ltd. All rights reserved.