Fluid flow in a single rough-walled rock fracture has been extensively studied over the last three decades. All but few of these studies, however, have been done with Newtonian fluids and unidirectional flow in rectangular fractures. Notwithstanding the importance of such setups for theoretical understanding of fundamental issues in fracture flow, practical applications in drilling and petroleum engineering often involve radial flow of a non-Newtonian fluid. An example is a borehole intersecting a natural fracture during drilling in a fractured rock. In this study, steady-state incompressible radial flow from a circular well into a self-affine rough-walled fracture was simulated numerically using the lubrication theory approximation. The fluid rheology was power law. The flow behavior index was equal to 0.6, 0.8, 1.0 (Newtonian), 1.2, or 1.4. Asperities diverted the flow from an axisymmetric radial pattern that would be observed in a smooth-walled fracture. The extent of the deviation from radial flow was found to increase as the fluid became more shear-thickening. To reveal finer details of the flow, a tracer was introduced at the borehole wall and was transported by the flow. The front of the tracer propagating into the fracture was found to become slightly smoother with a more shear-thickening fluid. In the vicinity of contacts between fracture faces a more shear-thickening fluid could deliver the tracer closer to the contact spots.