Supercritical CO2 extraction and response surface optimization of ginkgolic acids from ginkgo biloba exopleura

Lufei Tian; Minghao Zhou; Xiaomei Pan; Guomin Xiao; Yunqing Liu

Korean Journal of Chemical Engineering, Vol.32, No.8, 1649-1654, August, 2015

DOI10.1007/s11814-014-0363-1 Export Citation

Supercritical CO2 extraction and response surface optimization of ginkgolic acids from ginkgo biloba exopleura

Lufei Tian, Minghao Zhou, Xiaomei Pan, Guomin Xiao^†, and Yunqing Liu

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China

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Supercritical (Sc)-CO2 extraction was adopted to extract ginkgolic (G.) acids from ginkgo biloba exopleura. Response surface optimization was employed to maximize extraction recovery of G. acids from ginkgo biloba exopleura. The effects of pressure, temperature, CO2 mass flow rate, dosage of entrainer and extraction static-dynamic time on the yield of G. acids were investigated in detail, and the central composite design was used to maximize the extraction recovery of G. acids. The amounts of G. acids were analyzed by HPLC with the mixture of methanol and acetic acid solution as the mobile phase. The optimal process parameters for sc-CO2 extraction were determined to be: 31.3MPa extraction pressure, 46.1 oC extraction temperature and 11.1 g min-1 CO2 flow rate, 30mL ethanol entrainer, 1 h extraction static time and 2 h dynamic time. Under the conditions of optical extraction process, the average G. acids extraction rate was 74mg g-1.

Keywords:Supercritical (Sc)-CO2 Extraction;Ginkgolic (G.) Acids;Ginkgo Biloba Exopleura;Response Surface Optimization

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[Referenced By]

[1] Van Beek TA, J. Chromatogr. A, 967, 21 (2002)

[2] Major RT, Science, 157, 1270 (1967)

[3] Chen JJ, Zhang T, Jiang B, Mu WM, Miao M, Carbohydr. Polym., 87, 40 (2010)

[4] Castillo-Juarez I, Rivero-Cruz F, Celis H, Romero I, J. Ethnopharmacol., 114, 72 (2007)

[5] Itokawa H, Totsuka N, Nakahara K, Maezuru M, Takeya K, Kondo M, Inamatsu M, Morita H, Chem Pharm Bull, 37, 1619 (1989)

[6] Gomez AM, Lopez CP, de la Ossa EM, J. Chem. Eng., 61, 227 (1996)

[7] Kersch C, van Roosmalen MJE, Woerlee GF, Witkamp GJ, Ind. Eng. Chem. Res., 39(12), 4670 (2000)

[8] Valderrama JO, Perrut M, Majewski W, J. Chem. Eng. Data, 48(4), 827 (2003)

[9] Brunner G, J. Supercrit. Fluids, 47(3), 574 (2009)

[10] Sahena F, Zaidul ISM, Jinap S, Karim AA, Abbas KA, Norulaini NAN, Omar AKM, J. Food Eng., 95(2), 240 (2009)

[11] Marsili R, Callahan D, J. Chromatogr. Sci., 31, 422 (1993)

[12] Ghoreishi SM, Bataghva E, Dadkhah AA, Chem. Eng. Technol., 35(1), 133 (2012)

[13] Tong Y, Gao LJ, Xiao GM, Pan XM, Chem. Eng. Technol., 34(2), 241 (2011)

[14] Ye CL, Lai YF, Chem. Eng. Technol., 35(4), 646 (2012)

[15] Bernardo-Gil G, Oneto C, Antunes P, Rodrigues MF, Empis JM, Eur. Food Res. Technol., 212, 170 (2001)

[16] Oliveira R, Rodrigues MF, Bernardo-Gil MG, J. Am. Oil Chem. Soc., 79, 225 (2002)

[17] Ozkal SG, Yener ME, Bayindirli L, LWT Food Sci. Technol., 38, 611 (2005)

[18] Ozkal SG, Yener ME, Salgn U, Mehmetoglu U, Eur. Food Res. Technol., 220, 74 (2005)

[19] Yu J, Dandekar DV, Toledo RT, Singh RK, Patil BS, Food Chem., 105, 1026 (2007)

[20] Wang J, Sun BG, Cao YP, Tian Y, Li XL, Food Chem., 106, 804 (2008)

[21] Eikani MH, Golmohammad F, Rowshanzamir S, J. Food Eng., 80(2), 735 (2007)

[22] Wanasundara PKJPD, Shahidi F, J. Food Sci., 61, 604 (1996)

[23] Sanal IS, Bayraktar E, Mehmetoglu UU, Calimli A, J. Supercrit. Fluids, 34(3), 331 (2005)