화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.31, 15-25, November, 2015
DOI10.1016/j.jiec.2015.07.016  Export Citation
Engineered photo-responsive materials for near-infrared-triggered drug delivery
Hyun Jun Cho, Minsub Chung1, and Min Suk Shim†
  • Division of Bioengineering, Incheon National University, Incheon 406-772, Republic of Korea
  • 1Department of Chemical Engineering, Hongik University, Seoul 121-791, Republic of Korea
E-mail:
Near-infrared (NIR) light-responsive drug delivery systems have gained increasing interest in biomedical applications due to their spatiotemporal and on-demand drug release. This review summarizes recent progress in development of various photo-responsive materials for NIR lighttriggered drug release, with particular emphasis on their molecular designs and formulations as well as photo-reaction mechanisms. Various NIR light-responsive materials have been developed mainly by incorporating NIR light-responsive photochromic moieties. The photo-reaction mechanisms of NIR light-responsive materials for NIR light-triggered drug release include photo-induced transition of hydrophobicity.hydrophilicity, photo-cleavage reaction, and photo-induced heating, which induce disruption of the drug carriers for drug release. This review also highlights an emerging technology of utilizing upconverting nanoparticles (UCNPs) to significantly enhance the NIR light-sensitivity of the currently developed photo-responsive drug carriers. This review demonstrates that NIR-responsive drug delivery systems capable of spatiotemporal and on-demand drug release are highly desired to translate the promise of drug delivery for clinical therapy.
Keywords:Near-infrared (NIR) light;Drug delivery;Photochromic moieties;Nanoparticles
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