Theranostics dye integrated zwitterionic polymer for in vitro and in vivo photothermal cancer therapy

Eun Bi Kang; Jung Eun Lee; Ji Hoon Jeong; Gibaek Lee; Insik In; Sung Young Park

Journal of Industrial and Engineering Chemistry, Vol.33, 336-344, January, 2016

DOI10.1016/j.jiec.2015.10.026 Export Citation

Theranostics dye integrated zwitterionic polymer for in vitro and in vivo photothermal cancer therapy

Eun Bi Kang¹, Jung Eun Lee², Ji Hoon Jeong², Gibaek Lee^{1, 3}, Insik In^{4, 5, †}, and Sung Young Park^{1, 5, †}

¹Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea
²School of Pharmacy, Sungkyunkwan University, 300 Cheoncheon-dong, Jangan-gu, Suwon, Gyeonggi-do 440-746, Republic of Korea
³, Korea
⁴Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea
⁵Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea

E-mail:,

We report that combining diagnostic bioimaging fluorescence and photothermal therapeutic (PTT) within a single nano-platform can be used to simultaneously and accurately diagnose and ablate tumors. The integrated pH with thermo-responsive poly(dimethylaminoethyl methacrylate-co-N-isopropyla-cylamide) sulfobetaine (PDNS) backbone carrier retained optical bioimaging from boron dipyrro-methane (BODIPY) and sufficient photothermal generation is ensured by integrating IR825 within this same theranostic system. BODIPY (fluorescence dye) with IR825 (NIR dye) quaternized zwitterionic PDNS (IR825/BOD-PDNS) showed pH and temperature-dependent fluorescence emissions and NIR irradiated in vitro photothermal toxicity to cancer cells. This fluorescence platform maximizes the antitumor response, monitors treatment condition, and successfully ablates tumors with thermal energy.

Keywords:Bioimaging;BODIPY;IR825;Zwitterionic;Photothermal therapy

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Lim DK, Barhoumi A, Wylie RG, Reznor G, Langer RS, Kohane DS, Nano Lett., 13, 4075 (2013)
Shan G, Weissleder R, Hilderbrand SA, Theranostics, 3, 267 (2013)
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Sharker SM, Jeong CJ, Kim SM, Lee JE, Jeong JH, In I, Lee H, Park SY, Chem. Asian J., 9, 2921 (2014)
Sharker SM, Kim SM, Lee JE, Choi KH, Shin G, Lee S, Lee KD, Jeong JH, Lee H, Park SY, J. Control. Release, 217, 211 (2015)
Biju V, Chem. Soc. Rev., 43, 744 (2014)
Wark AW, Lee J, Kim S, Faisal SN, Lee HJ, J. Ind. Eng. Chem., 16(2), 169 (2010)
Lee SY, Kim SH, Kim SM, Lee H, Lee G, Park SY, New J. Chem., 38, 2225 (2014)
Dickerson EB, Dreaden EC, Huang X, El-Sayed IH, Chu H, Pushpanketh S, McDonald JF, El-Sayed MA, Cancer Lett., 269, 57 (2008)
Schmaljohann D, Adv. Drug Deliv. Rev., 58, 1655 (2006)
Sharker SM, Kim SM, Lee JE, Jeong JH, In I, Lee KD, Lee H, Park SY, Nanoscale, 7, 5468 (2015)
Decuzzi P, Godin B, Tanaka T, Lee SY, Chiappini C, Liu X, Ferrari M, J. Control. Release, 141, 320 (2010)
Yin YJ, Guo N, Wang CX, Rao QQ, Ind. Eng. Chem. Res., 53(37), 14322 (2014)
Kohane DS, Langer R, Chem. Sci., 1, 441 (2010)
Sharker SM, Kim SM, Kim SH, In I, Lee H, Park SY, J. Mater. Chem. B, 3, 5833 (2015)
Sharker SM, Lee JE, Kim SH, Jeong JH, In I, Lee H, Park SY, Biomaterials, 61, 229 (2015)
Liu Y, Ai K, Liu J, Deng M, He Y, Lu L, Adv. Mater., 35, 1353 (2013)
Torchilin V, Adv. Drug Deliv. Rev., 63, 131 (2011)
Zheng X, Zhou F, Wu B, Chen WR, Xing D, Mol. Pharm., 9, 514 (2012)
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[Referenced By]

[1] Ferrari M, Nat. Rev. Cancer, 5, 161 (2005)

[2] Sahoo SK, Labhasetwar V, Drug Discov. Today, 8, 1112 (2003)

[3] Luo S, Zhang E, Su Y, Cheng T, Shi C, Biomaterials, 32, 7127 (2011)

[4] Melamed JR, Edelstein RS, Day ES, ACS Nano, 9, 6 (2015)

[5] Lim DK, Barhoumi A, Wylie RG, Reznor G, Langer RS, Kohane DS, Nano Lett., 13, 4075 (2013)

[6] Shan G, Weissleder R, Hilderbrand SA, Theranostics, 3, 267 (2013)

[7] Klajn R, Chem. Soc. Rev., 43, 148 (2014)

[8] Cheng L, He WW, Gong H, Wang C, Chen Q, Cheng ZP, Liu Z, Adv. Funct. Mater., 23(47), 5893 (2013)

[9] Yao J, Yang M, Duan YX, Chem. Rev., 114(12), 6130 (2014)

[10] Garcia-Moreno I, Costela A, Campo L, Sastre R, Amat-Guerri F, Liras M, Arbeloa FL, Prieto JB, Arbeloa IL, J. Phys. Chem. A, 108(16), 3315 (2004)

[11] Mosaiab T, Shin C, Choi PH, Shin G, Lee S, Choi KH, Yoo ES, Lee J, In I, Park SY, New J. Chem., 37, 3845 (2013)

[12] Sharker SM, Jeong CJ, Kim SM, Lee JE, Jeong JH, In I, Lee H, Park SY, Chem. Asian J., 9, 2921 (2014)

[13] Sharker SM, Kim SM, Lee JE, Choi KH, Shin G, Lee S, Lee KD, Jeong JH, Lee H, Park SY, J. Control. Release, 217, 211 (2015)

[14] Biju V, Chem. Soc. Rev., 43, 744 (2014)

[15] Wark AW, Lee J, Kim S, Faisal SN, Lee HJ, J. Ind. Eng. Chem., 16(2), 169 (2010)

[16] Lee SY, Kim SH, Kim SM, Lee H, Lee G, Park SY, New J. Chem., 38, 2225 (2014)

[17] Dickerson EB, Dreaden EC, Huang X, El-Sayed IH, Chu H, Pushpanketh S, McDonald JF, El-Sayed MA, Cancer Lett., 269, 57 (2008)

[18] Schmaljohann D, Adv. Drug Deliv. Rev., 58, 1655 (2006)

[19] Sharker SM, Kim SM, Lee JE, Jeong JH, In I, Lee KD, Lee H, Park SY, Nanoscale, 7, 5468 (2015)

[20] Decuzzi P, Godin B, Tanaka T, Lee SY, Chiappini C, Liu X, Ferrari M, J. Control. Release, 141, 320 (2010)

[21] Yin YJ, Guo N, Wang CX, Rao QQ, Ind. Eng. Chem. Res., 53(37), 14322 (2014)

[22] Kohane DS, Langer R, Chem. Sci., 1, 441 (2010)

[23] Sharker SM, Kim SM, Kim SH, In I, Lee H, Park SY, J. Mater. Chem. B, 3, 5833 (2015)

[24] Sharker SM, Lee JE, Kim SH, Jeong JH, In I, Lee H, Park SY, Biomaterials, 61, 229 (2015)

[25] Liu Y, Ai K, Liu J, Deng M, He Y, Lu L, Adv. Mater., 35, 1353 (2013)

[26] Torchilin V, Adv. Drug Deliv. Rev., 63, 131 (2011)

[27] Zheng X, Zhou F, Wu B, Chen WR, Xing D, Mol. Pharm., 9, 514 (2012)

[28] Yang H, Fung SY, Liu M, Angew. Chem.-Int. Edit., 50, 9643 (2011)

[29] Wang C, Wang G, Wang Z, Zhang X, Chem. Eur. J., 17, 3322 (2011)