Here, we report high performance catalysts designed using nanowire supports. Specifically, nickel clusters supported on Zinc Oxide (ZnO) nanowires and gamma-alumina found to be highly active for ultra-deep desulfurization and aromatic hydrogenation of diesel. They were also found to be highly active for ultradeep desulfurization of gasoline and kerosene. The catalysts reduced sulfur from diesel, gasoline, and kerosene fuels containing sulfur as high as approximately 200 ppm to less than 1 ppm with sustained activity over testing periods of 100-150 h. The feed contained some of the most difficult to remove sulfur compounds such as 4-methyldibenzothiophene (MDBT),4,6-dimethyldibenzothiophene (DMDBT). In addition to activity towards ultra-deep desulfurization, these catalysts have shown to be active towards saturate/hydrogenate aromatics in diesel at moderate reaction conditions (30 bar, 290 C, and LHSV 2.2 h(-1)). The active catalytic site was determined to be a super Ni rich NixZny phase which seemed to remain essentially sulfur free during the reaction. The regenerated catalyst showed reasonable activity toward desulfurization of gasoline. (C) 2015 Elsevier B.V. All rights reserved.