Due to their harmful effects, finding the optimal catalysts for Sulfur containing Volatile Organic Compounds (S-VOC) oxidation is an important environmental challenge. A series of Pt-Cu catalysts supported on alumina (Al2O3), silica (SiO2) and silica doped alumina (Al2O3)(0.8)(SiO2)(0.2) were prepared and tested in the catalytic oxidation of dimethyldisulfide (DMDS). Characterization of the catalysts revealed that the performance of the catalyst is related to the interaction between Pt-Cu active phase and the supports. DMDS conversion on the Pt-Cu/Al2O3 catalyst was found to be close to that of the Pt-Cu/(Al2O3)(0.8)(SiO2)(0.2) catalyst. However, doping the Al2O3 substrate by SiO2 led to a more selective and stable catalyst. (C) 2015 Elsevier B.V. All rights reserved.