Fuel reactivity controlled compression ignition (RCCI) concept has arisen as a solution to control premixed combustion (PCI) strategies, which avoids soot and NOx formation by promoting a lean air-fuel mixture and low temperature combustion. Thus, this study is focused on investigating the effects of different engine operating variables over combustion, to be able to suggest suitable strategies for extending the RCCI operation from low to full load, in a HD single-cylinder research engine. Different strategies are implemented at low, medium and high load, varying fuel and air reactivity, by means of parametrical studies. Performance and emissions results are analyzed combining engine testing with 3D-CFD modeling. Based on those results, an overlimit function is used to select the best engine settings for each operating point. Finally, engine emissions and performance results from that RCCI operation are compared with conventional Diesel combustion (CDC). Results suggest that double injection strategies should be used for RCCI operation from low to mid load. However, from high to full load operation, single injection strategies should be used, mainly to avoid excessive in-cylinder pressure gradients. In addition, it is confirmed the suitability of RCCI combustion to overcome the soot-NOx trade-off characteristic of CDC, from 6 to 24 bar of BMEP, while improving fuel consumption. (C) 2015 Elsevier Ltd. All rights reserved.