The upcoming emission legislation for sea-going vessels issued by the international marine organization requires drastic reduction in nitric oxides. A well-known approach for meeting these requirements is to reduce the in-cylinder temperature prior to combustion by using the so-called Miller cycle. However, the mere use of this technique presents the actual limits due to long ignition delay, which occurs when the compression temperature is very low. As a consequence, premixed combustion develops quickly, increasing the local temperature in the combustion chamber and favoring NOx formation. Splitting the fuel injection into a small pilot and a main injection can reduce the magnitude of the premixed combustion and the local in-cylinder temperatures. The work presented here is divided in two parts and is novel by being the first systematic study of split injection combined with Miller cycle in large-bore engines. In its first stage, an extensive study of the injection dwell with two intake valve closings and three timings of the main injection are analyzed. In the second stage, both injection events are shifted later in the power stroke with fixed injection dwell. Overall, the pilot injection reduced the ignition delay but dropped the peak of the premixed combustion only with the most advanced intake valve closing. This improved fuel economy, but provided no advantages as far as emissions are concerned. In addition, while increasing injection dwell reduced NOx emissions, it also increased fuel consumption. The highest achieved NOx reduction was close to 60%, with a small drawback in fuel economy. (C) 2015 Elsevier Ltd. All rights reserved.