Asymmetric Biginelli Reaction Catalyzed by Silicon, Titanium and Aluminum Oxides

Fedorova OV; Titova YA; Vigorov AY; Toporova MS; Alisienok OA; Murashkevich AN; Krasnov VP; Rusinov GL; Charushin VN

Catalysis Letters, Vol.146, No.2, 493-498, 2016

DOI10.1007/s10562-015-1666-5 Export Citation

Asymmetric Biginelli Reaction Catalyzed by Silicon, Titanium and Aluminum Oxides

Fedorova OV, Titova YA, Vigorov AY, Toporova MS, Alisienok OA, Murashkevich AN, Krasnov VP, Rusinov GL, Charushin VN

The asymmetric Biginelli reaction was investigated in the presence of N-[(2S,4R)-4-hydroxyprolyl]-(S)-1-phenylethylamine as chiral inducer and silicon, titanium or aluminum oxides (individual and mixed, bulk and nanosized) as heterogeneous catalysts. It has been shown that all studied oxides improve chemo- and stereoselectivity of the Biginelli reaction. [GRAPHICS]

Keywords:Asymmetric catalysis;The Biginelli reaction;Condensation;Nanoparticles;Chemoselectivity;Heterogeneous catalysis