Pervaporation is a well-established separation technology for the production of anhydrous solvents, but its distribution in the chemical industry is still limited to a few individual applications. Besides the need of high-selective membranes, the development of membrane modules adapted to the specific requirements of this process needs more research effort. Furthermore, only few modeling tools for the pervaporation process are available. In this work, a three-step modeling approach ranging from a shortcut to a rigorous model is developed. A hydrophobic membrane is characterized in a laboratory test cell for the separation of 2-butanol from water in a wide temperature and concentration range. The identified performance data are used to simulate the same separation task with an industrial-scale membrane module. The results are validated by experiments conducted with a novel membrane module in pilot scale.