In the past decades, many multicolumn chromatographic processes have been proposed and studied for multicomponent continuous separation. In this study, the optimal operation for ternary multicolumn chromatographic separation is obtained from a full superstructure which embeds many different operations. A multiobjective optimization problem was solved to analyze the trade-off between the throughput and the purity of the target component. It was found that the throughput of the optimal operation found from the full superstructure is significantly higher than that of the generalized full cycle scheme in our former publication in 2012.