Some essential conditions necessary to reach an autothermal regime in methane oxidative coupling on La2O3/MgO catalysts were investigated. The following three ways can be suggested to transfer the process into the autothermal regime: (1) higher initial concentrations of reagents; (2) larger reactor diameter; (3) optimization of the flow rate and the preheating temperature. It was found that the optimal temperature of the autothermal regime of methane oxidative coupling is governed by the nature of the catalyst.