The evolution of global energy supply chains leads to a raw material change in the chemical industry. Despite this change, the value-added chains of the chemical industry have to keep up their output of diverse high-quality products desired by the customers. C1 chemistry in combination with suitable conversion technologies yielding olefins and aromatics will play a key role in mastering this challenge. New chemical value-added chains have to be developed and assessed, resulting in an increasing importance of conceptual process design. All this will take place in what Ghemawat has called the World 3.0, a globally linked but regionally diverse world. This diversity creates further challenges for process design in the chemical industries. A systematic concept to address these challenges is given here, including strategies for optimization and decision support.