A regulation pool is usually built between Fenton and biological reactors in the present Fenton-biological joint processes to remove the detrimental effect of H2O2 on the microorganisms. In this paper, a novel integrative Fenton-like and upward flow biological filter bed (IBFB) was constructed to overcome this drawback. In the IBFB, the home-made Fenton-like catalyst pellets were filled at the bottom and a MnO2 layer was put between Fenton-like reactor and bioreactor to remove the residual H2O2. Experimental results show that Acid Orange 7 (AO7) degradation in the IBFB reaches as high as 96.4% due to the efficient home-made Fenton-like catalysts. More importantly, the IBFB not only removes the detrimental effect of H2O2, but also turns it into dissolved oxygen (DO). The high DO enhances the microbial metabolism in the upper bioreactor. Therefore, the IBFB attains chemical oxygen demand (COD) removal of 69.1%, 14.4% higher than the separate Fenton-like and biological filter bed (SBFB). Moreover, the cost of the construction and operation is lower than that of SBFB, because the regulation pool and the following pump are saved. This novel IBFB offers a new idea to develop a high efficient Fenton-like and biological filter bed (BFB) joint process. (C) 2015 Elsevier B.V. All rights reserved.