A spatially-encoded intermolecular single-quantum coherence pulse sequence is utilized to obtain high-resolution NMR spectra in inhomogeneous fields. To enhance sensitivities, a soft pulse was employed to solely excite solvent spins. Only inhomogeneous field information is exhibited along the indirect dimension, and spectral-width narrowing in the indirect dimension not only enhances the spectral sensitivity, but also increases measurable spectral widths in the direct dimension. The sequence shortens the acquisition time from minutes to seconds. A detailed theoretical analysis is provided. The sensitivity and the resolution of the method are proved by the studies of chemical and biological materials. (C) 2015 Elsevier B.V. All rights reserved.