화학공학소재연구정보센터
Chemical Physics Letters, Vol.634, 160-165, 2015
A study of the hydration of lysozyme in neat organic solvents using isothermal calorimetry: Effect of water solvation
The interaction enthalpies of the dried and hydrated lysozyme with neat organic solvents (DMSO, formamide, ethylene glycol, and methanol) were obtained at 25 degrees C. These organic solvents represent a series of liquids in which the water solvation enthalpy is gradually changed over a wide range. The interaction enthalpies of the dried lysozyme with neat organic solvents are exothermic. At high water content, the interaction enthalpies are endothermic for formamide and exothermic for DMSO, methanol, and ethylene glycol. The dehydration enthalpies of lysozyme in organic liquids may be endothermic or exothermic depending on the initial water content and the water solvation enthalpy. (C) 2015 Elsevier B.V. All rights reserved.