A kinetic study of the isomerization of 1-decene using a Rh-Biphephos catalyst was performed in order to parameterize a mechanistic kinetic model to observed experimental data. For the derivation of the kinetic model, a previously proposed catalytic cycle was revised regarding the catalyst pre-equilibrium including the formation of inactive or non-selective Rh-species. In order to estimate the model parameters and to support model reduction, a method based on parameter subset selection was extended and applied. Using this approach, sensitive kinetic parameters were identified and determined for the reduced kinetic model.