The development and application of module-based production plants is a strategy to respond to ever increasing demands on the global chemicals market. Similar to conventionally planned production plants the new developed plant type must be checked for safe use. Therefore, risk analysis methods have to be identified and applied effectively which ensure a safe operation. By using intra- and inter-modular safety assessments, a module data database and by assigning modules to an operating window the effort for achieving a safe production plant can be reduced.