Genipin 가교된 키토산/산화티타늄 나노복합체의 향균성을 포함한 특성 분석

Yangshuo Liu; Jiange Lu; Ming Li; Chiyang He

Polymer(Korea), Vol.40, No.2, 251-257, March, 2016

DOI10.7317/pk.2016.40.2.251 Export Citation

Genipin 가교된 키토산/산화티타늄 나노복합체의 향균성을 포함한 특성 분석

Characterization and Antibacterial Properties of Genipin-crosslinked Chitosan/TiO2 Nanocomposites

Yangshuo Liu^†, Jiange Lu, Ming Li, and Chiyang He

College of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430074, China

E-mail:

Novel nanocomposite films consisting of genipin-crosslinked chitosan (GC), poly(ethylene glycol) (PEG), titanium dioxide (TiO2), and silver (Ag) nanoparticles were prepared containing various amounts of TiO2 and Ag nanoparticles. The effects of composition and TiO2 nanoparticles on the physico-chemical properties of nanocomposite sampleswere evaluated by X-ray diffraction and infrared analysis. The greatest swellings were observed in the acidic pH. GC/PEG/TiO2/Ag nanocomposite showed the pH-sensitive swelling behavior and the improved mechanical properties. These nanocomposites were shown to have antibacterial activity towards Escherichia coli. GC/PEG/TiO2/Ag composite films had higher antimicrobial activities than GC/PEG and GC/PEG/TiO2 nanocomposite films. GC/PEG/TiO2/Ag composite films have potential application as wound dressings.

Keywords:chitosan;swelling;titanium dioxide;silver;antimicrobial activity;wound dressing

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[2] Deepachitra R, Ramnath V, Sastry TP, RSC. Adv., 4, 62717 (2014)

[3] Archana D, Singh BK, Dutta J, Dutta PK, Carbohydr. Polym., 95, 530 (2013)

[4] Morgado PI, Lisboa PF, Ribeiro MP, Miguel SP, Simoes PC, Correia IJ, Aguiar-Ricardo A, J. Membr. Sci., 469, 262 (2014)

[5] Fujishima A, Honda K, Nature, 238, 37 (1972)

[6] Robel I, Subramanian V, Kuno M, Kamat PV, J. Am. Chem. Soc., 128(7), 2385 (2006)

[7] Ko YS, Han YH, Yim JH, Polym. Korea, 38(4), 525 (2014)

[8] Zheng S, Cai Y, O’Shea KE, J. Photochem. Photobiol., 210, 61 (2010)

[9] Hua D, Cheuk K, Wei-ning Z, Chen W, Chang-fa X, Trans. Nonferrous Met. Soc. China, 17, s700 (2007)

[10] Caballero L, Whitehead KA, Allen NS, Verran J, Dyes Pigment., 86, 56 (2010)

[11] Guin D, Manorama SV, Latha JNL, Singh S, J. Phys. Chem. C, 111, 13393 (2007)

[12] Arabatzis IM, Stergiopoulos T, Bernard MC, Labou D, Neophytides SG, Falaras P, Appl. Catal. B: Environ., 42(2), 187 (2003)

[13] Chen EZ, Su HJ, Tan TW, J. Chem. Technol. Biotechnol., 86(3), 421 (2011)

[14] Yang YC, Wen JW, Wei JH, Xiong R, Shi J, Pan CX, Appl. Mater. Inter., 5, 6201 (2013)

[15] Ohko Y, Tatsuma T, Fujii T, Naoi K, Niwa C, Kubota Y, Fujishima A, Nat. Mater., 2(1), 29 (2003)

[16] Naoi K, Ohko Y, Tatsuma T, J. Am. Chem. Soc., 126(11), 3664 (2004)

[17] Huo HY, Su HJ, Jiang W, Tan TW, Biochem. Eng. J., 43, 2 (2009)

[18] Xi X, Zhen W, Bian S, Wang W, Polym. Korea, 39(4), 601 (2015)

[19] Muzzarelli RAA, Tarsi R, Filippini O, Giovanetti E, Biagini G, Varaldo PE, Antimicrob. Agents Chemother., 34, 2019 (1990)

[20] Danbuo Y, The Essential Methods for Miscellaneous Diseases, 2nd Edn, Wang Y, Editor, People’s Health Publishers, PR China, 1984.

[21] Shindo S, Hosokawa Y, Hosokawa I, Ozaki K, Matsuo T, BiochimieI, 107, 391 (2014)

[22] Wang JW, Hon MH, J. Appl. Polym. Sci., 96(4), 1083 (2005)

[23] Muzzarelli RAA, Carbohydr. Polym., 77, 1 (2009)

[24] Wei DW, Sun WY, Qian WP, Ye YZ, Ma XY, Carbohydr. Res., 344, 2375 (2009)

[25] Gunister E, Pestreli D, Unlu CH, Atıcı O, Gungor N, Carbohydr. Polym., 67, 358 (2007)

[26] Kitkulnumchai Y, Ajavakom A, Sukwattanasinitt M, Cellulose, 15, 599 (2008)

[27] Amin SA, Pazouki M, Hosseinnia A, Powder Technol., 196(3), 241 (2009)

[28] Carreira AS, Goncalves FAMM, Mendonca PV, Gil MH, Coelho JFJ, Carbohydr. Polym., 80, 618 (2010)

[29] Shariatinia Z, Fazli M, Food Hydrocolloids, 46, 112 (2015)

[30] Seaman S, J. Am. Podiat. Med. Assn., 92, 24 (2002)

[31] Amin MA, Abdel-Raheem IT, Arch. Pharm. Res., 37, 1016 (2014)

[32] Tan SP, McLoughlin P, O’Sullivan L, Prieto ML, Gardiner GE, Lawlor PG, Hughes H, Int. J. Pharm., 456, 10 (2013)

[33] Pereira R, Carvalho A, Vaz DC, Gil MH, Mendes A, Bartolo P, Int. J. Biol. Macromol., 52, 221 (2013)

[34] Moore J, Perkins A, Adv. Skin Wound Care, 23, 544 (2010)

[35] Amin KAM, Panhuis M, Polymer, 47, 590 (2012)

[36] Cho KH, Park JE, Osaka T, Park SG, Electrochim. Acta, 51(5), 956 (2005)

[37] Kanna M, Wongnawa S, Mater. Chem. Phys., 110(1), 166 (2008)