Complex processes often work with multiple operation regions, it is critical to develop effective monitoring approaches to ensure the safety of chemical processes. In this work, a discriminant local consistency Gaussian mixture model (DLCGMM) for multimode process monitoring is proposed for multimode process monitoring by integrating LCGMM with modified local Fisher discriminant analysis (MLFDA). Different from Fisher discriminant analysis (FDA) that aims to discover the global optimal discriminant directions, MLFDA is capable of uncovering multimodality and local structure of the data by exploiting the posterior probabilities of observations within clusters calculated from the results of LCGMM. This may enable MLFDA to capture more meaningful discriminant information hidden in the high-dimensional multimode observations comparing to FDA. Contrary to most existing multimode process monitoring approaches, DLCGMM performs LCGMM and MFLDA iteratively, and the optimal subspaces with multi-Gaussianity and the optimal discriminant projection vectors are simultaneously achieved in he framework of supervised and unsupervised learning. Furthermore, monitoring statistics are established on each cluster that represents a specific operation condition and two global Bayesian inference based fault monitoring indexes are established by combining with all the monitoring results of all clusters. The efficiency and effectiveness of the proposed method are evaluated through UCI datasets, a simulated multimode model and the Tennessee Eastman benchmark process. (C)2015 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.