The shrinking supplies of freshwater globally, coupled with strict environmental regulations, have driven the manufacturing industry towards sustainable water management for the minimisation of freshwater intake and wastewater generation. By using process integration and its enabling tools, this work considers the synthesis of an optimal water network with multiple regeneration capabilities. Development of the proposed framework is achieved by embedding a subnetwork of detailed electrodialysis models within a water network. Based on a superstructure and fixed flowrate, the optimisation problem is formulated as an MINLP model and solved in GAMS/DICOPT. To demonstrate the applicability of the proposed mathematical model a literature case study on a pulp and paper plant is presented and the results indicate a potential of 12% savings in freshwater intake, 16% reduction in wastewater generated and a 14% saving in the total annualised cost for the entire network. (C) 2015 Elsevier Ltd. All rights reserved.