Titanium dioxide/Nano-graphite (TiO2/Nano-G) composite was synthesized by a sol-gel method and TiO2/Nano-G electrode was prepared in hot-press approach. The composite was characterized by X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FT-IR), scanning electrons microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical performance of the TiO2/Nano-G anode electrode was investigated through cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electro-catalytic performance was evaluated by the yield of (OH)-O-center dot radicals, degradation of methyl orange and ceftriaxone sodium. The results demonstrated that TiO2 nanoparticles were dispersed on the surface and interlamination of the Nano-G uniformly, TiO2/Nano-G electrode owned higher electro-catalytic oxidation activity and stability than Nano-G electrode. Degradation rate of ceftriaxone sodium within 120 min by TiO2(40)/Nano-G electrode was 97.7%. And (OH)-O-center dot radicals given by TiO2/Nano-G electrode was higher than that of Nano-G electrode and DSA (Ti/IrO2-RuO2) electrode. The excellent electro-catalytic performance could be ascribed to the admirable conductive property of the Nano-G and more production of (OH)-O-center dot offered by TiO2(40)/Nano-G electrode. (C) 2015 Elsevier Ltd. All rights reserved.