Impact of entropy generation for the peristaltic flow in a tube is investigated. The entropy generation number due to heat transfer and fluid friction is formulated. The velocity and temperature distributions across the tube are presented along with pressure attributes. Exact analytical solution for velocity and temperature profile is obtained. Velocity, temperature, pressure gradient, pressure rise, Bejan number and streamlines are presented for radius of the tube a, Hartmann number M, amplitude ratio epsilon, Brinkman number B-r and flow Q presented graphically. It is found that the entropy generation number attains high values in the region close to the walls of the tube, while it gains low values near the center of the tube. (C) 2014 Elsevier Ltd. All rights reserved.