A detailed investigation was aimed based on numerical thermodynamic survey and artificial neural network (ANN) modeling of the trigeneration system. The results are presented in two pivotal frameworks namely the sensitivity analysis and ANN prediction capability of proposed modeling. The underlying operative parameters were chosen as input parameters from different cycles and components, while the exergy efficiency, exergy loss, coefficient of performance, heating load exergy, lambda, gas turbine power, exergy destruction, actual outlet air compressor temperature, and heat recovery gas steam generator (HRSG) outlet temperature were taken as objective output parameters for the modeling purpose. Up to now, no significant step was taken to investigate the compound power plant with thermodynamic analyses and network predictability hybrid in such a detailed oriented approach. It follows that multilayer perceptron neural network with back propagation algorithm deployed with 10-8-9 configuration results in the modeling reliability ranged within R-2 = 0.995-0.999. When dataset treated with trainlm learning algorithm and diversified neurons, the mean square error (MSE) is obtained equal to 0.2175. This denotes a powerful modeling achievement in both scientific and industrial scale to save considerable computational cost on combined cooling, heating, and power system in accomplishment of boosting the energy efficiency and system maintenance. C) 2015 Elsevier Ltd. All rights reserved.