In this study, the effect of ultrasonic pretreatment on the physicochemical property changes and methane production potential of anaerobic digestion of food waste was investigated. The study, involving a laboratory experimentation by sonicating 200 mL of food waste sample, was investigated at different sonication times (2, 4, 6, 8, 10 min), and the specific energy input ranged from 5,396 to 25,997 kJ/kg total solid. The experimental results found that the mean particle size diameter (d(50)) of the ultrasonically treated food waste decreased from 59 to 21.9 mu m with the specific surface area increasing from 0.523 to 1.2 mu m(2)/g. This is evidenced in the food waste morphological structure changes from particles or granules varying in size and shape from small to large and round to oval or unsymmetrical shaped when the food waste samples were sonicated in the range of 2-10 min as shown by scanning electron microscopy. The value of soluble chemical oxygen demand was increased about 34-40% while the degree of disintegration was recorded as 57.15, 61.10, 71.08, 68.94, and 68.68%, respectively. The CODsolubilization was achieved around 11.4, 11.8, 13.4, 12.7, and 13.2%, when the food waste sample was sonicated at 2, 4, 6, 8, and 10 min, respectively. This CODsolubilization correlated well with DD when the linear relationship was shown by R-2 = 0.945. The result shows that the use of sonicated food waste in the anaerobic digestion process has increased about 45.9, 40.3, 46.6, 64.4, and 70.5% of cumulative CH4 production rates in the food waste sample sonicated at 2, 4, 6, 8, and 10 min, respectively, when compared to the non-sonicated food waste sample.