Data on corresponding solid-liquid equilibrium of mercaptosuccinic acid is essential for a preliminary study of industrial applications. In this paper, we focused on solubility and solution thermodynamics of mercaptosuccinic acid. By gravimetric method, the solid-liquid equilibrium of mercaptosuccinic acid was measured in (methanol + ethyl acetate) binary solvent mixtures from 278.15 K to 333.15 K under atmosphere pressure. The solubility data were then modeled using modified Apelblat equation, a variant of the combined nearly ideal binary solvent/Redich-Kister (CNIBS/R-K) model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation and CNIBS/R-K model have the low MD (mean deviation). In addition, the thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated by the van't Hoff analysis. (C) 2015 Elsevier B.V. All rights reserved.