The reactive extraction (RE) of carboxylic and,dicarboxylic acids, such as cis,cis-muconic acid (CCMA), is a promising integrated approach towards an efficient downstream processing development. Dicarboxylic acids have a high potential to be used as precursors for polymerization reactions or as monomers for new and innovative polymers and carrbe produced by biocatalytic production. In this work water-insoluble long chain amines and water-soluble short chain amines were evaluated as extractants for the RE of CCMA. The biocompatible organic solvent ethyl oleateand mixtures of ethyl oleate and a polar modifier were used as organic phase for all experiments presented. Three out of six water-insoluble amines (di-n-octylamine (D-C8), tri-n-hexalamine (T-C6), tri-n-octylamine (T-C8)) were shown to be applicable extractants for the RE of CCMA. A systematic investigation of the mutual influence of amine and modifier on RE performance was performed for the first time. The best performing systems (D-C8: b(D-C8) = 0.1 mol kg(org)(-1) W1-dodecanol = 0.3/T-C8: b(T-C8) = 0.15 mol kg(org)(-1),W1-dodecanol = 0.1) in terms of yield and inhibition of a third phase presented in this work, lead to yields of X similar to 0.95-0.96 +/- 0.04. (C) 2015 Elsevier B.V. All rights reserved.