A general kinetic model has been developed to simulate the three-phase solvent-free hydrogenation of 2-methyl-3-butyn-2-ol (MBY) over a commercial palladium-based catalyst. A LangmuirHinshelwood mechanism with noncompetitive adsorption between hydrogen and the organic species is assumed. Gasliquid mass-transfer resistance is included in the model. Experiments were carried out in a stirred slurry reactor to estimate the kinetic parameters. The proposed model is able to predict the concentration profiles of the species involved during MBY hydrogenation, at varying temperatures (313-353 K), pressures (3.0-10.0 bar), and catalyst loadings (0.075-0.175 wt %). The model predictions were successfully validated using additional experimental runs conducted under different operating conditions and at a lower initial concentration of MBY.