Experimental results on the etherification of glycerol by isobutylene using Indion-130 catalyst are presented. Experiments were carried out at five different, temperatures between 45 and 85 degrees C in an autoclave with mechanical stirring. Isobutylene was produced in situ from tert-butyl alcohol in another autoclave connected in series: Experiments were conducted for a duration, of 24 h with sample collection (for analysis) every 2 h. Samples were analyzed by gas chromatography for monitoring mono-, di-, and tri-tert-butyl glycerol ethers (MTBG,. DTBG, and TTBG). The studies reveal that the optimal temperature for maximum production of DTBG is 55 degrees C. A multilump kinetic model has been developed, and global rate constants have been evaluated.