A novel fluorinated amine monomer (CF3(CF2)(6)CONH(CH2CH2NH)(2)CH2CH2NH2, fluorinated polyamine) was synthesized and utilized to perform interfacial polymerization with trimesoyl chloride, producing thin-film composite nanofiltration membranes with low surface free energy. Filtration experiments were performed using simulated brackish water (1.0 g/L of salt) and simulated dye wastewater (0.1 g/L of dyes). The membrane prepared under optimal conditions exhibited a flux of 12.9 L/(m(2) h), while the rejection of Orange GII reached 94.7% under 0.2 MPa. The antifouling experiment results verified that the resultant membrane (surface free energy as low as 23.0 mJ/m(2)) could effectively resist and drive off foulants such as bovine serum albumin, humic acid, and oil due to the lower adhesion force between foulants and membrane. The excellent antifouling property of the resultant membrane (minimal value of total flux decline ratio similar to 9.1%, maximum value of flux recovery ratio 99.8%) would promote the application of nanofiltration in wastewater treatment.