A multieffect refrigeration system that is based on a waste-heat-driven organic Rankine cycle that could produce refrigeration output of different magnitudes at different levels of temperature is presented. The proposed system is integration of combined ejector-absorption refrigeration cycle and ejector expansion Joule-Thomson (EJT) cooling cycle that can meet the requirements of air-conditioning, refrigeration, and cryogenic cooling simultaneously at the expense of industrial waste heat. The variation of the parameters that affect the system performance such as industrial waste heat temperature, refrigerant turbine inlet pressure, and the evaporator temperature of ejector refrigeration cycle (ERC) and EJT cycles was examined, respectively. It was found that refrigeration output and thermal efficiency of the multieffect cycle decrease considerably with the increase in industrial waste heat temperature, while its exergy efficiency varies marginally. A thermal efficiency value of 22.5% and exergy efficiency value of 8.6% were obtained at an industrial waste heat temperature of 210 degrees C, a turbine inlet pressure of 1.3MPa, and ejector evaporator temperature of 268K. Both refrigeration output and thermal efficiency increase with the increase in turbine inlet pressure and ERC evaporator temperature. Change in EJT cycle evaporator temperature shows a little impact on both thermal and exergy efficiency values of the multieffect cycle. Analysis of the results clearly shows that the proposed cycle has an effective potential for cooling production through exploitation of lost energy from the industry. Copyright (c) 2014 John Wiley & Sons, Ltd.