Objective: This study investigated the bond strength of two resin cements (Panavia F 2.0 and Multilink N) to different CAD/CAM materials: resin nanoceramic (RNC; Lava Ultimate), hybrid ceramic (HC; Vita Enamic), zirconia-reinforced lithium silicate ceramic (ZLDC; Vita Suprinity), and lithium disilicate glass-ceramic (LDG; IPS e.max CAD HT). Material and methods: CAD/CAM blocks of 2-mm thickness were sectioned with a slow-speed diamond-saw sectioning machine. The slabs were then embedded in autopolymerizing acrylic resin (n=12), and resin cements were applied to the surface of the specimens. All specimens were stored in water for 24h and subjected to 5000 thermal cycles. Bond strength was measured by means of the shear bond strength test. The data were statistically analyzed by two-way ANOVA and Tukey LSD post hoc tests. Results: The results of the two-way ANOVA test indicated that the bond strength values varied significantly depending on the CAD/CAM restorative materials, resin cements, and interaction of these variables (p<0.05). The RNC group showed the highest bond strength for Panavia F 2.0 (p<0.05); there were no significant differences among other CAD/CAM materials for Panavia F 2.0 (p>0.05). The LDG group showed the highest bond strength for Multilink N, it was followed by the ZLDC group (p<0.05); there were no significant differences between RNC and HC groups (p>0.05). Conclusions: Choosing resin cements for restorations should be done carefully because bond strength values vary significantly depending on the resin cement and CAD/CAM restorative material.