This research aimed to investigate the effect of the calcination temperature and the CeO2 to nanotubes (CNTs) weight ratio on the performance of Pt/CeO2-CNTs hybrid nanotube for methanol oxidation. The catalysts were prepared by microwave-assisted polyol process. Electro-chemical results showed that Pt/CeO2-CNTs hybrid nanotube catalyst with the calcination temperature of 280 degrees C and the weight ratio of 4:4 is more active and stable than others. The properties of catalyst were characterized by X-ray diffraction, high-resolution transmission electron microscopy, and scanning transmission electron microscopy-energy dispersive spectroscopy elemental mapping. The increased catalytic efficiency of Pt in the Pt/CeO2-CNTs hybrid nanotube catalysts resulted from its smaller Pt nanoparticles and good contact with CeO2 and CNTs simultaneously.