An efficient one-pot heterogeneous process for producing chiral alpha,beta-epoxy-chalcones from the corresponding aldehydes and ketones, has been described. The nanohybrid materials based on poly-L-leucine immobilised into rehydrated hydrotalcites did not require any pre-activation and were easily recovered and recycled for four consecutive runs without losing their catalytic efficiency in terms of conversion, total selectivity towards the corresponding epoxy-chalcones and excellent enantioselectivity. (C) 2015 Elsevier Inc. All rights reserved.