Dissolution trend and solubility data of calcium sulfate dihydrate (CaSO(4 center dot)2H(2)O gypsum) in aqueous Na, Ca, Mg, and Al chloride salt solutions have been studied at 278.15 K to 308.15 K The concentration ranges were up to 4.5 mol.L-1 for NaCl, 3.0 mol.L-1 for MgCl2, 2.0 mol.L-1 for CaCl2, and 1.6 mol.L-1 for AlCl3, respectively. Measurement results show that except for CaCl2, the other three salts allow the solubility of gypsum to rise a lot first and then descend smoothly after attaining the maximum. Because of common ions effect, the solubility of CaSO4 center dot 2H(2)O drops sharply in CaCl2 solution at low concentration and continues to fall almost linearly as concentration exceeds 0.2 mol.kg(-1). Impacts of Na, Mg, Al chloride salts on solubility of CaSO4 center dot 2H(2)O are explained on the basis of dissolution and thermodynamic equilibrium. The solubility of CaSO4 center dot 2H(2)O in AlCl3 solution is highest compared with that in NaCl nd MgCl2 solution because two sulfur-bearing chemical complex Al(SO4)(2)(-)(aq) and AlSO4+(aq) are expected to be formed in solution. Besides, a number of H+ ions produced in AlCl3 solution further promote the dissolution of CaSO4 center dot 2H(2)O. In addition, it is demonstrated that CaSO4 center dot 2H(2)O is fairly stable in the above chloride salts solution of high concentration (4.5 mol.L-1 for NaCl, 3.0 mol.L-1 for MgCl2, 2.0 mol.L-1 for CaCl2 and 1.6 mol.L-1 for AlCl3) for 2 weeks at 308.15 K by the evidence that no new peaks emerged in X-ray power diffraction results.