Hydrate dissociation data are presented for systems of refrigerants (R134a, R410a, and R507) + water + CaCl2 at varying salt concentrations. The R134a + water + CaCl2 system was measured at salt concentrations of (0, 0.358, 0.591, and 0.756) mol.kg(-1) in the temperature range of (276.2 to 283) K and a pressure range of (0.125 to 0.428) MPa. The systems composed of {R410a or R507} + water + CaCl2 were measured at salt concentrations of (0, 0.358 and 0.756) mol.kg(-1) in the temperature range of (274.7 to 293) K and a pressure range of (0.179 to 1.421) MPa. The isochoric pressure-search method was used for all the hydrate measurements. The data generated can be used in the design and optimization of industrial wastewater treatment and desalination processes. The presence of CaCl2 in the aqueous solutions shifts the hydrate-liquid water-vapor (H-L-w-V) equilibrium phase boundary toward lower temperatures as salt concentration increases. The experimental data were modeled using a combination of the solid solution theory of van der Waals and Platteeuw, the Aasberg-Petersen et al. model, and the Peng-Robinson equation of state with classical mixing rules. The model provides a good correlation of the experimental hydrate dissociation data.