Starting with metal-organic frameworks (MOFs), a facile process was demonstrated toward the synthesis of porous FeP nanocubes. Herein, Prussian blue nanocubes were used as iron-based MOFs precursors, and converted into FeP nanocubes through the thermal phosphidation reaction. Then, the FeP nanocubes were exploited as a peroxidase mimetic, which not only has the advantages of low cost, high stability, and easy preparation, but also follows Michaelis-Menten behaviors and shows strong affinity to substrates. On the basis of high catalytic activity of FeP nanocubes, a rapid, and convenient approach was developed for the colorimetric detection of H2O2 from 2 mu M to 130 mu M and with a detection limit of 0.62 mu M. The good catalytic activity and high stability make the porous FeP nanocubes a useful catalyst for a wide range of potential applications in catalysis and biotechnology. (C) 2015 Elsevier Inc. All rights reserved.