Since non-Newtonian fluid behavior are not uncommon in practice, especially in modern applications of colloid and interface science, assessment of how serious is the deviation of the existing results for Newtonian fluids due to fluid nature is highly desirable and necessary. Here, we extend previous analyses for the diffusiophoresis of a particle in a Newtonian fluid to that in a non-Newtonian fluid choosing Carreau fluids as an example. Results gathered reveal that due to the shear-thinning property of the fluid considered, the difference between the particle mobility in a Carreau fluid and that in the corresponding Newtonian fluid can be on the order of 100%. In addition, this difference has a local minimum as the thickness of double layer varies. (C) 2015 Elsevier Inc. All rights reserved.