The aim of this work is to formulate biofunctional hybrid materials (HMs) with quercetin (QC) and silica particles (Sips) by simple methods such as sol-gel and QC conjugation. Physicochemical characterization included particle size, zeta potential (zeta), FTIR and SEM imaging. Spherical particles with ca. 115 nm in diameter were produced, zeta and FTIR demonstrated that QC conjugation was successfully achieved. Electrochemical analyses performed by cyclic voltammetry (CV) suggested that potential binding sites between QC and SiPs may be at functional groups from A ring or C ring, affecting the transfer electron of resorcinol moiety. Iron chelating activity and lipid peroxidation assays showed that after conjugation to SiPs, QC decreased its metal chelating activity, but anti-radical properties is maintained. Our results demonstrated that our proposed method is simple and effective to obtain bio-functional HMs. Our findings prove to be useful in the design of protective approaches against lipid oxidation in food, pharmaceutical, and cosmetics fields. (C) 2015 Elsevier Inc. All rights reserved.