QDs를 이용한 키토산-골드와 키토산-실버 나노약물전달체 제조

이용춘; 강익중; Yong-Choon Lee; Ik-Joong Kang

Korean Chemical Engineering Research, Vol.54, No.2, 200-205, April, 2016

DOI10.9713/kcer.2016.54.2.200 Export Citation

QDs를 이용한 키토산-골드와 키토산-실버 나노약물전달체 제조

Preparation of Chitosan-Gold and Chitosan-Silver Nanodrug Carrier Using QDs

이용춘, 강익중 ^†

가천대학교 화공생명공학과, 13120 경기도 성남시 수정구 복정동 산 65

Yong-Choon Lee, and Ik-Joong Kang^†

Department of Chemical and Biochemical Engineering, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam, Gyunggi, 13120, Korea

E-mail:

초록

본 연구에서는 최근 많은 분야에서 응용되고 있는 형광물질인 양자점을 생명고분자인 키토산과 반응시켜 얻은 나노입자와 금속성 골드 나노입자, 그리고 실버 나노입자로 외부를 코팅하여 나노약물 전달체를 얻을 수 있었다. 키토산은 생체고분자로써 무독성이며 인체적합성 고분자이다. 양자점은 2~10 nm의 크기를 가지는 반도체성 나노입자이다. 양자점은 생명분자나 생명단백질의 비슷한 크기를 갖으며, 그 크기에 따라 알맞은 가시광선 영역의 빛을 발산할 수 있도록 조절 가능하므로, 세포 바이오 마킹, 약물전달체 등에 효과적으로 쓰일 수 있다. 따라서 키토산 나노입자 말단의 아민기와 양자점의 카르복실기가 아미드결합을 형성하여 반응하게 조절하였다. 양자점의 독성을 완화시키기 위해 코팅재료로 사용된 금속성 나노입자 중 골드나노입자는 약 5~10 nm의 크기를 가지고 있고, 인체에 무해하고 음전하를 띄어서 양전하를 띈 고분자와 쉽게 복합체를 형성할 수 있는 장점이 있다. 향균성으로 잘 알려진 실버나노입자는 약 5 nm의 크기를 가지고 있고, 은 나노입자로 코팅을 하면 미생물 감염을 미리 방지 할 수 있는 장점을 가지고 있다. 본 연구에서 만들어진 QDs-키토산-골드 & QDs-키토산-실버 나노쉘의 입자크기는 약 100 nm의 크기를 갖었으며, 목적하는 바 형광특성을 잘 보여주고 있었다. 이러한 입자들은 정전기적 상호작용에 의하여 각각 골드나노입자와 실버나노입자로 코팅되어 나노 약물전달체로 완성할 수 있었다.

A drug transport carrier could be used for safe send of drugs to the affected region in a human body. The chitosan is adequate for the drug delivery carrier because of adaptable to living body. The gold, a metallic nanoparticles, tends to form a nano complex at rapidly when it combined with chitosan because of its negative charge. having energy from the other, outer gold nano-complex make heat due to its property to release the contained drugs to the target area. Silver could be also formed an useful biocompatible nano-composites with chitosan which should be used as an useful drug transfer carrier because its special ability to protect microbial contamination. Being one of the oxidized nano metals, Fe3O4 is nontoxic and has been used for its magnetic characteristics. In this study, the control of catalyst, reducing agent, and solvent amount. The chitosan-Fe3O4-gold & silver nanoshell have been changed to form about 100 nm size by ionic bond between the amine group, an end group of chitosan, and the metal. It was observed the change in order to seek for its optimum reaction condition as a drug transfer carrier.

Keywords:Chitosan-gold and Chitosan-silver Nanoshell;Quantum-Dots;Nanodrug Carrier

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Zhen-Hua L, Carbohydr. Polym., 98(1), 1173 (2013)
Chunlan W, Yahui H, Xingfei L, Ronghui L, J. Functional Foods, 7, 180 (2014)
Sarah B, Sergio T, Kjell F, Tiziana A, Neuropharmacology, 82, 11 (2014)
Richard, Edden AE, Neuro Image, 86, 43 (2014)
Mingjun D, Zhihan N, Panpan L, Yanjun Z, Electrochim. Acta, 132(20), 465 (2014)
Jae-Wook L, Ik-Joong K, Bull. Korean Chem. Soc., 36(2), 672 (2015)
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Jae-Wook L, Ik-Joong K, Bull. Korean Chem. Soc., 34(1), 237 (2013)

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