The performance of energy infrastructures under extreme loading conditions, especially for blast and impact conditions, is of great importance despite the low probability for such events to occur. Due to catastrophic consequences of structural failure, it is crucial to improve the resistance of energy infrastructures against the impact of blasts. A TNT equivalent method is used to simulate a petroleum gas vapor cloud explosion when analyzing the dynamic responses of a spherical tank under external blast loads. The pressure distribution on the surface of a 1000 m(3) spherical storage tank is investigated. The dynamic responses of the tank, such as the distribution of effective stress, structural displacement, failure mode and energy distribution under the blast loads are studied and the simulation results reveal that the reflected pressure on the spherical tank decreases gradually from the equator to the poles of the sphere. However, the effects of the shock wave reflection are not so evident on the pillars. The structural damage of the tank subjected to blast loads included partial pillar failure from bending deformation and significant stress concentration, which can be observed in the joint between the pillar and the bottom of the spherical shell. The main reason for the remarkable deformation and structural damage is because of the initial internal energy that the tank obtained from the blast shock wave. The liquid in the tank absorbs the energy of impact loads and reduces the response at the initial stage of damage after the impact of the blast. (C) 2015 Elsevier Ltd. All rights reserved.