In this paper, Bi2S3 microflowers have been successfully synthesized via a facile one-pot hydrothermal method and characterized by X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray analysis, and X-ray photoelectron spectroscopy. Then the Bi2S3 microflowers were deposited on patterned ITO glass substrates by dip-coating to fabricate photodetectors. The photoresponse properties using Bi2S3 microflowers as a representative system show a significantly enhanced conductivity and the current-voltage characteristic exhibit ca. 1.7 orders of magnitude larger than the dark current. The response and decay times are estimated to be similar to 227 and 880 ms, respectively, indicating that flower-like Bi2S3 may be an excellent candidate for high-speed and high-sensitivity photoelectrical switches and light-sensitive devices.