The solubility of several gases and vapors in glassy ethyl cellulose (EC) over wide ranges of temperature and pressure is described by means of a thermodynamic model, which specifically accounts for the nonequilibrium volumetric properties of EC. The behaviors of polymer/penetrant mixtures are represented by the well-established nonequilibrium lattice fluid model (NELF) in its latest development, suitable to be used in a pure predictive fashion for the representation of the volume swelling of the polymer matrix, as induced by penetrant sorption. The analysis reveals the ability of the model to describe all the experimental trends, and a sole binary parameter for each polymer/penetrant couple is considered. The NELF model allows the satisfactory prediction of the thermodynamic properties of all polymer/solute systems examined, in the entire range considered for temperature and vapor fugacity. (C) 2014 Elsevier B.V. All rights reserved.