Biological activity compounds of figues, isolated from the fruit of figue, these compounds were showed strong antifungal activity against C, albicans ATCC 10231. C, utilis. S, cerevisiae ATCC 9763. A, niger ATCC 9029. Among them, sample No. [G] showed potent inhibition activity. Generally, many samples showed biological activity in vitro test. The above results showed the possibility of the development of new antifungal agents, So, ketoconazole derivatives [1,2,3,] were synthesized by the reaction of cis-[2-(2,4-Dichlorophenyl)-2-(1-H-imidazol-1-yl)-1,3-dioxolan-4-yl] Methane Sulfonate with isolated fig compounds. and antifungal activity was tested in vitro. and their antifungal activity were evaluated.